3qgl

{{STRUCTURE_3qgl| PDB=3qgl | SCENE= }}

===Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) in complex with the ESESKV peptide corresponding to the C-terminal tail of GIRK3===

{{ABSTRACT_PUBMED_21422294}}

==Function==

[[http://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity). [[http://www.uniprot.org/uniprot/IRK9_RAT IRK9_RAT]] This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).

==About this Structure==

[[3qgl]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QGL OCA].

 

<ref group="xtra">PMID:021422294</ref><references group="xtra"/><references/>

[[Category: Balana, B.]]

[[Category: Choe, S.]]

[[Category: Kwiatkowski, W.]]

[[Category: Protein binding]]