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3qk3

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{{STRUCTURE_3qk3| PDB=3qk3 | SCENE= }}
 
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===Crystal structure of human beta-crystallin B3===
 
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==Disease==
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==Crystal structure of human beta-crystallin B3==
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[[http://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN]] Non-syndromic congenital cataract. Cataract, congenital, nuclear, autosomal recessive 2 (CATCN2) [MIM:[http://omim.org/entry/609741 609741]]: A congenital cataract affecting the central nucleus of the eye. Nucler cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15914629</ref>
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<StructureSection load='3qk3' size='340' side='right'caption='[[3qk3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qk3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk3 OCA], [https://pdbe.org/3qk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN] Non-syndromic congenital cataract. Cataract, congenital, nuclear, autosomal recessive 2 (CATCN2) [MIM:[https://omim.org/entry/609741 609741]: A congenital cataract affecting the central nucleus of the eye. Nucler cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15914629</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/CRBB3_HUMAN CRBB3_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.
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*[[Crystallin 3D structures|Crystallin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3qk3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK3 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Cocking, R.]]
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[[Category: Bountra C]]
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[[Category: Delft, F von.]]
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[[Category: Cocking R]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi C]]
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[[Category: Kavanagh, K.]]
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[[Category: Kavanagh K]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Muniz, J.]]
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[[Category: Muniz J]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Pilka, E.]]
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[[Category: Pilka E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yue WW]]
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[[Category: Yue, W W.]]
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[[Category: Von Delft F]]
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[[Category: Beta b3]]
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[[Category: Cataract]]
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[[Category: Crybb3]]
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[[Category: Crystallin]]
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[[Category: Eye lens protein]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of human beta-crystallin B3

PDB ID 3qk3

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