3qmb

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{{STRUCTURE_3qmb| PDB=3qmb | SCENE= }}
 
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===Structural Basis of Selective Binding of Nonmethylated CpG Islands by the CXXC Domain of CFP1===
 
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{{ABSTRACT_PUBMED_21407193}}
 
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==Function==
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==Structural Basis of Selective Binding of Nonmethylated CpG Islands by the CXXC Domain of CFP1==
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[[http://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN]] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref>
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<StructureSection load='3qmb' size='340' side='right'caption='[[3qmb]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3qmb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMB FirstGlance]. <br>
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[[3qmb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMB OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmb OCA], [https://pdbe.org/3qmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmb RCSB], [https://www.ebi.ac.uk/pdbsum/3qmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmb ProSAT]</span></td></tr>
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<ref group="xtra">PMID:021407193</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C B.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bian CB]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Kania, J.]]
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[[Category: Edwards AM]]
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[[Category: Lam, R.]]
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[[Category: Kania J]]
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[[Category: Min, J.]]
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[[Category: Lam R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Cxxc-type zn finger]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Nucleus speckle]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Unmethylated cpg motif]]
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Current revision

Structural Basis of Selective Binding of Nonmethylated CpG Islands by the CXXC Domain of CFP1

PDB ID 3qmb

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