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3q5i

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{{STRUCTURE_3q5i| PDB=3q5i | SCENE= }}
 
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===Crystal Structure of PBANKA_031420===
 
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==About this Structure==
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==Crystal Structure of PBANKA_031420==
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[[3q5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5I OCA].
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<StructureSection load='3q5i' size='340' side='right'caption='[[3q5i]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q5I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5i OCA], [https://pdbe.org/3q5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q5i RCSB], [https://www.ebi.ac.uk/pdbsum/3q5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q5i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDPK1_PLABA CDPK1_PLABA] Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK4 and CDPK5 (PubMed:32866196). In the mosquito midgut and during the last stage of male gamete exflagellation, may play a role in the rupture of the host erythrocyte membrane (PubMed:22817984). In the mosquito midgut, required for the differentiation of the zygote into the ookinete by promoting the translational activation of a subset of repressed mRNAs; these mRNAs are kept repressed in the zygote by the DOZI- or CITH-containing mRNP complexes (PubMed:22817984, PubMed:24265753). Dispensable during the asexual blood stage (PubMed:24265753).[UniProtKB:P62344]<ref>PMID:22817984</ref> <ref>PMID:24265753</ref> <ref>PMID:32866196</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium berghei]]
[[Category: Plasmodium berghei]]
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[[Category: Amani, M.]]
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[[Category: Amani M]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Cossar, D.]]
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[[Category: Cossar D]]
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[[Category: Crombet, L.]]
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[[Category: Crombet L]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hassani, A.]]
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[[Category: Hassani A]]
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[[Category: Hui, R.]]
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[[Category: Hui R]]
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[[Category: Hutchinson, A.]]
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[[Category: Hutchinson A]]
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[[Category: Neculai, A M.]]
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[[Category: Neculai AM]]
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[[Category: Panico, E.]]
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[[Category: Panico E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sullivan H]]
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[[Category: Sullivan, H.]]
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[[Category: Vedadi M]]
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[[Category: Vedadi, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Wernimont AK]]
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[[Category: Wernimont, A K.]]
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[[Category: Calcium dependent protein kinase]]
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[[Category: Cdpk]]
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[[Category: Malaria]]
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[[Category: Phosphotransferase]]
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[[Category: Plasmodium]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of PBANKA_031420

PDB ID 3q5i

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