3dls

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{{STRUCTURE_3dls| PDB=3dls | SCENE= }}
 
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===Crystal structure of human PAS kinase bound to ADP===
 
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{{ABSTRACT_PUBMED_20943661}}
 
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==Function==
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==Crystal structure of human PAS kinase bound to ADP==
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[[http://www.uniprot.org/uniprot/PASK_HUMAN PASK_HUMAN]] Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.<ref>PMID:16275910</ref> <ref>PMID:17052199</ref> <ref>PMID:17595531</ref> <ref>PMID:21181396</ref> <ref>PMID:21418524</ref> <ref>PMID:20943661</ref>
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<StructureSection load='3dls' size='340' side='right'caption='[[3dls]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3dls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DLS FirstGlance]. <br>
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[[3dls]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dls OCA], [https://pdbe.org/3dls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dls RCSB], [https://www.ebi.ac.uk/pdbsum/3dls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dls ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3dls TOPSAN]</span></td></tr>
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<ref group="xtra">PMID:020943661</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PASK_HUMAN PASK_HUMAN] Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.<ref>PMID:16275910</ref> <ref>PMID:17052199</ref> <ref>PMID:17595531</ref> <ref>PMID:21181396</ref> <ref>PMID:21418524</ref> <ref>PMID:20943661</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dls_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dls ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Antonysamy, S.]]
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[[Category: Antonysamy S]]
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[[Category: Bonanno, J B.]]
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[[Category: Bonanno JB]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Gheyi, T.]]
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[[Category: Gheyi T]]
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[[Category: Iizuka, M.]]
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[[Category: Iizuka M]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Romero R]]
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[[Category: Romero, R.]]
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[[Category: Russell M]]
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[[Category: Russell, M.]]
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[[Category: Rutter J]]
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[[Category: Rutter, J.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Wasserman SR]]
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[[Category: Wasserman, S R.]]
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[[Category: Atp-binding]]
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[[Category: Drug discovery]]
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[[Category: Kinase]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Nucleotide-binding]]
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[[Category: Nysgxrc]]
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[[Category: Pas kinase]]
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[[Category: Pask]]
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[[Category: Phosphoprotein]]
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[[Category: Protein kinase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human PAS kinase bound to ADP

PDB ID 3dls

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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