3pz2

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{{STRUCTURE_3pz2| PDB=3pz2 | SCENE= }}
 
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===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP===
 
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==Disease==
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==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP==
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[[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents.
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<StructureSection load='3pz2' size='340' side='right'caption='[[3pz2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz2 OCA], [https://pdbe.org/3pz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (By similarity).
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*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3pz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ2 OCA].
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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==Reference==
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[[Category: Alexandrov K]]
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<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>
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[[Category: Blankenfeldt W]]
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[[Category: Mus musculus]]
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[[Category: Bon RS]]
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[[Category: Protein geranylgeranyltransferase type II]]
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[[Category: Goody RS]]
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[[Category: Alexandrov, K.]]
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[[Category: Guo Z]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Stigter EA]]
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[[Category: Bon, R S.]]
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[[Category: Waldmann H]]
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[[Category: Goody, R S.]]
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[[Category: Guo, Z.]]
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[[Category: Stigter, E A.]]
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[[Category: Waldmann, H.]]
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[[Category: Chimera protein]]
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[[Category: Fusion protein]]
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[[Category: Protein prenylation]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

PDB ID 3pz2

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