2gjt

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[[Image:2gjt.gif|left|200px]]<br /><applet load="2gjt" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gjt, resolution 2.15&Aring;" />
 
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'''Crystal structure of the human receptor phosphatase PTPRO'''<br />
 
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==About this Structure==
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==Crystal structure of the human receptor phosphatase PTPRO==
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2GJT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJT OCA].
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<StructureSection load='2gjt' size='340' side='right'caption='[[2gjt]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Protein-tyrosine-phosphatase]]
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<table><tr><td colspan='2'>[[2gjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJT FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Barr, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjt OCA], [https://pdbe.org/2gjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjt RCSB], [https://www.ebi.ac.uk/pdbsum/2gjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjt ProSAT]</span></td></tr>
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[[Category: Das, S.]]
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</table>
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[[Category: Delft, F von.]]
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== Disease ==
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[[Category: Edwards, A.]]
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[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN] Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:[https://omim.org/entry/614196 614196]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.<ref>PMID:21722858</ref>
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[[Category: Eswaran, J.]]
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== Function ==
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[[Category: Knapp, S.]]
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[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN] Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).<ref>PMID:19167335</ref>
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[[Category: Niesen, F.]]
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== Evolutionary Conservation ==
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[[Category: Papagrigoriou, E.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: SGC, Structural Genomics Consortium.]]
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Check<jmol>
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[[Category: Savitsky, P.]]
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<jmolCheckbox>
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[[Category: Sundstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjt_consurf.spt"</scriptWhenChecked>
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[[Category: Turnbull, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Ugochukwu, E.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Weigelt, J.]]
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</jmolCheckbox>
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[[Category: CL]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjt ConSurf].
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[[Category: glepp1]]
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<div style="clear:both"></div>
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[[Category: ptpro]]
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<div style="background-color:#fffaf0;">
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[[Category: ptpu2]]
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== Publication Abstract from PubMed ==
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[[Category: sgc]]
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Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential secondary substrate-binding pocket is frequently found in phosphatases, and this has implications for both substrate recognition and development of selective inhibitors. Structural comparison identified four diverse catalytic loop (WPD) conformations and suggested a mechanism for loop closure. Enzymatic assays revealed vast differences in PTP catalytic activity and identified PTPD1, PTPD2, and HDPTP as catalytically inert protein phosphatases. We propose a "head-to-toe" dimerization model for RPTPgamma/zeta that is distinct from the "inhibitory wedge" model and that provides a molecular basis for inhibitory regulation. This phosphatome resource gives an expanded insight into intrafamily PTP diversity, catalytic activity, substrate recognition, and autoregulatory self-association.
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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[[Category: tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:32:24 2008''
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Large-scale structural analysis of the classical human protein tyrosine phosphatome.,Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Muller S, Knapp S Cell. 2009 Jan 23;136(2):352-63. PMID:19167335<ref>PMID:19167335</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gjt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Barr A]]
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[[Category: Das S]]
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[[Category: Edwards A]]
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[[Category: Eswaran J]]
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[[Category: Knapp S]]
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[[Category: Niesen F]]
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[[Category: Papagrigoriou E]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull A]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the human receptor phosphatase PTPRO

PDB ID 2gjt

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