4ka4
From Proteopedia
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| - | {{STRUCTURE_4ka4| PDB=4ka4 | SCENE= }} | ||
| - | ===Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)=== | ||
| - | == | + | ==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)== |
| - | [[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN | + | <StructureSection load='4ka4' size='340' side='right'caption='[[4ka4]], [[Resolution|resolution]] 2.60Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KA4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ka4 OCA], [https://pdbe.org/4ka4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ka4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ka4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ka4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Athanasiadis A]] |
| - | [[Category: Sanctis | + | [[Category: De Sanctis D]] |
| - | [[Category: | + | [[Category: De Rosa M]] |
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Current revision
Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)
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