3rk6

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{{STRUCTURE_3rk6| PDB=3rk6 | SCENE= }}
 
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===Crystal structure of the middle domain of human Paip1===
 
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{{ABSTRACT_PUBMED_21539810}}
 
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==Function==
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==Crystal structure of the middle domain of human Paip1==
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[[http://www.uniprot.org/uniprot/PAIP1_HUMAN PAIP1_HUMAN]] Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:9548260</ref> <ref>PMID:11051545</ref>
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<StructureSection load='3rk6' size='340' side='right'caption='[[3rk6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3rk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RK6 FirstGlance]. <br>
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[[3rk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RK6 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rk6 OCA], [https://pdbe.org/3rk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3rk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rk6 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:021539810</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/PAIP1_HUMAN PAIP1_HUMAN] Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:9548260</ref> <ref>PMID:11051545</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hilgenfeld, R.]]
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[[Category: Large Structures]]
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[[Category: Lei, J.]]
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[[Category: Hilgenfeld R]]
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[[Category: Mesters, J R.]]
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[[Category: Lei J]]
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[[Category: Eif3]]
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[[Category: Mesters JR]]
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[[Category: Eif4a]]
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[[Category: Heat fold]]
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[[Category: Pabp]]
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[[Category: Translation regulator]]
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Current revision

Crystal structure of the middle domain of human Paip1

PDB ID 3rk6

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