3rf9
From Proteopedia
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| - | {{STRUCTURE_3rf9| PDB=3rf9 | SCENE= }} | ||
| - | ===X-ray structure of RlmN from Escherichia coli=== | ||
| - | {{ABSTRACT_PUBMED_21527678}} | ||
| - | == | + | ==X-ray structure of RlmN from Escherichia coli== |
| - | [[3rf9]] is a 2 chain structure with sequence from [ | + | <StructureSection load='3rf9' size='340' side='right'caption='[[3rf9]], [[Resolution|resolution]] 2.20Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3rf9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RF9 FirstGlance]. <br> |
| - | < | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rf9 OCA], [https://pdbe.org/3rf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rf9 RCSB], [https://www.ebi.ac.uk/pdbsum/3rf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rf9 ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/RLMN_ECOLI RLMN_ECOLI] Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation.<ref>PMID:18025251</ref> <ref>PMID:21415317</ref> <ref>PMID:22891362</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Boal AK]] |
| + | [[Category: Booker SJ]] | ||
| + | [[Category: Grove TL]] | ||
| + | [[Category: McLaughlin MI]] | ||
| + | [[Category: Rosenzweig AC]] | ||
| + | [[Category: Yennawar N]] | ||
Current revision
X-ray structure of RlmN from Escherichia coli
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