3rq3

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{{STRUCTURE_3rq3| PDB=3rq3 | SCENE= }}
 
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===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form===
 
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==Function==
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==Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form==
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[[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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<StructureSection load='3rq3' size='340' side='right'caption='[[3rq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3rq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RQ3 FirstGlance]. <br>
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[[3rq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ3 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rq3 OCA], [https://pdbe.org/3rq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3rq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rq3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Guo, H.]]
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[[Category: Almo SC]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
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[[Category: Guo H]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Nathenson SG]]
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[[Category: Nathenson, S G.]]
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[[Category: Ramagopal UA]]
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[[Category: Ramagopal, U A.]]
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[[Category: Rubinstein R]]
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[[Category: Rubinstein, R.]]
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[[Category: Samanta D]]
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[[Category: Samanta, D.]]
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[[Category: Adhesion]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Ifn]]
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[[Category: Ig-domain]]
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[[Category: Immune receptor]]
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[[Category: Immune system]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Tigit]]
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Current revision

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form

PDB ID 3rq3

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