3s24

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{{STRUCTURE_3s24| PDB=3s24 | SCENE= }}
 
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===Crystal structure of human mRNA guanylyltransferase===
 
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{{ABSTRACT_PUBMED_21636784}}
 
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==Function==
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==Crystal structure of human mRNA guanylyltransferase==
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[[http://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN]] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
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<StructureSection load='3s24' size='340' side='right'caption='[[3s24]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3s24]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S24 FirstGlance]. <br>
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[[3s24]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S24 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0137&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s24 OCA], [https://pdbe.org/3s24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s24 RCSB], [https://www.ebi.ac.uk/pdbsum/3s24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s24 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:021636784</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arnold, E.]]
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[[Category: Large Structures]]
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[[Category: Bauman, J D.]]
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[[Category: Arnold E]]
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[[Category: Chu, C.]]
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[[Category: Bauman JD]]
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[[Category: Das, K.]]
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[[Category: Chu C]]
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[[Category: Guan, R.]]
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[[Category: Das K]]
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[[Category: Montelione, G T.]]
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[[Category: Guan R]]
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[[Category: Qiu, W.]]
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[[Category: Montelione GT]]
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[[Category: Shatkin, A J.]]
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[[Category: Qiu W]]
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[[Category: Thyminski, J R.]]
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[[Category: Shatkin AJ]]
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[[Category: Capping enzyme]]
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[[Category: Thyminski JR]]
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[[Category: Ce]]
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[[Category: Ctd]]
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[[Category: Gt/dna ligase fold]]
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[[Category: Gtase]]
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[[Category: Hce]]
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[[Category: Hydrolase]]
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[[Category: M7gpppn cap]]
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[[Category: Transcription factor spt5]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human mRNA guanylyltransferase

PDB ID 3s24

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