3re3
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| - | {{STRUCTURE_3re3| PDB=3re3 | SCENE= }} | ||
| - | ===Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase from Francisella tularensis=== | ||
| - | == | + | ==Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase from Francisella tularensis== |
| - | [[http://www.uniprot.org/uniprot/ISPF_FRATT ISPF_FRATT | + | <StructureSection load='3re3' size='340' side='right'caption='[[3re3]], [[Resolution|resolution]] 2.65Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3re3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RE3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.645Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3re3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3re3 OCA], [https://pdbe.org/3re3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3re3 RCSB], [https://www.ebi.ac.uk/pdbsum/3re3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3re3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ISPF_FRATT ISPF_FRATT] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107] | ||
==See Also== | ==See Also== | ||
| - | *[[MECDP synthase|MECDP synthase]] | + | *[[MECDP synthase 3D structures|MECDP synthase 3D structures]] |
| - | + | __TOC__ | |
| - | [[Category: Francisella tularensis subsp. tularensis]] | + | </StructureSection> |
| - | [[Category: | + | [[Category: Francisella tularensis subsp. tularensis SCHU S4]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Joachimiak | + | [[Category: Anderson WF]] |
| - | [[Category: Kim | + | [[Category: Joachimiak A]] |
| - | [[Category: Kwon | + | [[Category: Kim Y]] |
| - | [[Category: Makowska-Grzyska | + | [[Category: Kwon K]] |
| - | + | [[Category: Makowska-Grzyska M]] | |
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Current revision
Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase from Francisella tularensis
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