3rp1

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{{STRUCTURE_3rp1| PDB=3rp1 | SCENE= }}
 
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===Crystal structure of Human LAIR-1 in C2 space group===
 
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==Function==
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==Crystal structure of Human LAIR-1 in C2 space group==
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[[http://www.uniprot.org/uniprot/LAIR1_HUMAN LAIR1_HUMAN]] Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.<ref>PMID:9285412</ref> <ref>PMID:10229813</ref> <ref>PMID:10764762</ref> <ref>PMID:9692876</ref> <ref>PMID:11069054</ref> <ref>PMID:11160222</ref> <ref>PMID:12072189</ref> <ref>PMID:15939744</ref> <ref>PMID:15950745</ref> <ref>PMID:16380958</ref>
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<StructureSection load='3rp1' size='340' side='right'caption='[[3rp1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rp1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RP1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rp1 OCA], [https://pdbe.org/3rp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rp1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rp1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LAIR1_HUMAN LAIR1_HUMAN] Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.<ref>PMID:9285412</ref> <ref>PMID:10229813</ref> <ref>PMID:10764762</ref> <ref>PMID:9692876</ref> <ref>PMID:11069054</ref> <ref>PMID:11160222</ref> <ref>PMID:12072189</ref> <ref>PMID:15939744</ref> <ref>PMID:15950745</ref> <ref>PMID:16380958</ref>
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==About this Structure==
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==See Also==
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[[3rp1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RP1 OCA].
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*[[Leukocyte-associated immunoglobulin-like receptor|Leukocyte-associated immunoglobulin-like receptor]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Bonanno, J.]]
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[[Category: Almo SC]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Bonanno J]]
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[[Category: Nathenson, S.]]
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[[Category: Nathenson S]]
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[[Category: Ramagopal, U A.]]
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[[Category: Ramagopal UA]]
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[[Category: Sampathkumar, P.]]
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[[Category: Sampathkumar P]]
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[[Category: Toro, R.]]
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[[Category: Toro R]]
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[[Category: Yan, Q.]]
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[[Category: Yan Q]]
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[[Category: Collagen receptor]]
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[[Category: Collagen-binding]]
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[[Category: Ig-like]]
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[[Category: Immune system]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of Human LAIR-1 in C2 space group

PDB ID 3rp1

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