This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3rtl
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_3rtl| PDB=3rtl | SCENE= }} | ||
| - | ===Staphylococcus aureus heme-bound IsdB-N2=== | ||
| - | {{ABSTRACT_PUBMED_21574663}} | ||
| - | == | + | ==Staphylococcus aureus heme-bound IsdB-N2== |
| - | [[3rtl]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3rtl' size='340' side='right'caption='[[3rtl]], [[Resolution|resolution]] 1.45Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3rtl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTL FirstGlance]. <br> |
| - | < | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.453Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtl OCA], [https://pdbe.org/3rtl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rtl RCSB], [https://www.ebi.ac.uk/pdbsum/3rtl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtl ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/ISDB_STAAN ISDB_STAAN] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence. IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Staphylococcus aureus subsp. aureus N315]] |
| - | [[Category: | + | [[Category: Arrieta AL]] |
| - | [[Category: | + | [[Category: Gaudin CFM]] |
| + | [[Category: Grigg JC]] | ||
| + | [[Category: Murphy MEP]] | ||
Current revision
Staphylococcus aureus heme-bound IsdB-N2
| |||||||||||
