We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2gte

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:27, 3 April 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gte.jpg|left|200px]]<br /><applet load="2gte" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2gte, resolution 1.40&Aring;" />
 
-
'''Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate'''<br />
 
-
==About this Structure==
+
==Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate==
-
2GTE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=VA:'>VA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTE OCA].
+
<StructureSection load='2gte' size='340' side='right'caption='[[2gte]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
[[Category: Drosophila melanogaster]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2gte]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTE FirstGlance]. <br>
-
[[Category: Ha, T.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
[[Category: Jones, D N.M.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VA:(Z)-OCTADEC-11-ENYL+ACETATE'>VA</scene></td></tr>
-
[[Category: Laughlin, J D.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gte OCA], [https://pdbe.org/2gte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gte RCSB], [https://www.ebi.ac.uk/pdbsum/2gte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gte ProSAT]</span></td></tr>
-
[[Category: Smith, D P.]]
+
</table>
-
[[Category: PO4]]
+
== Function ==
-
[[Category: VA]]
+
[https://www.uniprot.org/uniprot/OB76A_DROME OB76A_DROME] Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by binding to VA. May act by serving as an adapter that bridges the presence of gaseous pheromone molecules, cVA, to activation of specific neuronal receptors expressed on T1 olfactory neurons, possibly via a specific conformational change induced by cVA that in turn activates T1 receptors. T1 neurons are excited by the pheromone VA, while T2 neurons are inhibited by alcohols. Also binds to phthalates.<ref>PMID:9755202</ref> <ref>PMID:11238251</ref> <ref>PMID:14759510</ref> <ref>PMID:15664171</ref> <ref>PMID:16928861</ref> <ref>PMID:17943085</ref>
-
[[Category: odorant binding protein]]
+
== Evolutionary Conservation ==
-
[[Category: pheromone]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: pheromone binding protein]]
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/2gte_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gte ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:08 2008''
+
==See Also==
 +
*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Drosophila melanogaster]]
 +
[[Category: Large Structures]]
 +
[[Category: Ha T]]
 +
[[Category: Jones DNM]]
 +
[[Category: Laughlin JD]]
 +
[[Category: Smith DP]]

Current revision

Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate

PDB ID 2gte

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gte"
Personal tools