4hsa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:02, 27 November 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4hsa| PDB=4hsa | SCENE= }}
 
-
===Structure of interleukin 17a in complex with il17ra receptor===
 
-
{{ABSTRACT_PUBMED_23695682}}
 
-
==Disease==
+
==Structure of interleukin 17a in complex with il17ra receptor==
-
[[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:[http://omim.org/entry/613953 613953]]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
+
<StructureSection load='4hsa' size='340' side='right'caption='[[4hsa]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4hsa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSA FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsa OCA], [https://pdbe.org/4hsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsa RCSB], [https://www.ebi.ac.uk/pdbsum/4hsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsa ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The constituent polypeptides of the interleukin-17 family form six different homodimeric cytokines (IL-17A-F) and the heterodimeric IL-17A/F. Their interactions with IL-17 receptors A-E (IL-17RA-E) mediate host defenses while also contributing to inflammatory and autoimmune responses. IL-17A and IL-17F both preferentially engage a receptor complex containing one molecule of IL-17RA and one molecule of IL-17RC. More generally, IL-17RA appears to be a shared receptor that pairs with other members of its family to allow signaling of different IL-17 cytokines. Here we report crystal structures of homodimeric IL-17A and its complex with IL-17RA. Binding to IL-17RA at one side of the IL-17A molecule induces a conformational change in the second, symmetry-related receptor site of IL-17A. This change favors, and is sufficient to account for, the selection of a different receptor polypeptide to complete the cytokine-receptor complex. The structural results are supported by biophysical studies with IL-17A variants produced by site-directed mutagenesis.
-
==Function==
+
Crystal structures of interleukin 17A and its complex with IL-17 receptor A.,Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES, Griffor MC Nat Commun. 2013;4:1888. doi: 10.1038/ncomms2880. PMID:23695682<ref>PMID:23695682</ref>
-
[[http://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [[http://www.uniprot.org/uniprot/I17RA_HUMAN I17RA_HUMAN]] Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.<ref>PMID:21993848</ref> <ref>PMID:19838198</ref>
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[4hsa]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSA OCA].
+
</div>
 +
<div class="pdbe-citations 4hsa" style="background-color:#fffaf0;"></div>
-
==Reference==
+
==See Also==
-
<ref group="xtra">PMID:023695682</ref><references group="xtra"/><references/>
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
 +
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Liu, S.]]
+
[[Category: Large Structures]]
-
[[Category: Cytokine receptor]]
+
[[Category: Liu S]]
-
[[Category: Glycosylation]]
+
-
[[Category: Immune system-protein binding complex]]
+

Current revision

Structure of interleukin 17a in complex with il17ra receptor

PDB ID 4hsa

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4hsa"
Personal tools