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4kfg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The DNA Gyrase B ATP binding domain of Escherichia coli in complex with a small molecule inhibitor.== |
| + | <StructureSection load='4kfg' size='340' side='right'caption='[[4kfg]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfg OCA], [https://pdbe.org/4kfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfg RCSB], [https://www.ebi.ac.uk/pdbsum/4kfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Akers-Rodriguez S]] | ||
| + | [[Category: Bensen DC]] | ||
| + | [[Category: Lam T]] | ||
| + | [[Category: Tari LW]] | ||
Current revision
The DNA Gyrase B ATP binding domain of Escherichia coli in complex with a small molecule inhibitor.
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