4klz

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'''Unreleased structure'''
 
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The entry 4klz is ON HOLD until Paper Publication
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==Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis==
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<StructureSection load='4klz' size='340' side='right'caption='[[4klz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Shah, D.M., Kobayashi, M., Keizers, P.H, Tuin, A.W., Ab, E., Manning, L., Rzepiela, A.A., Andrews, M., Hoedemaeker, F.J., Siegal, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4klz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLZ FirstGlance]. <br>
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Description: Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klz OCA], [https://pdbe.org/4klz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klz RCSB], [https://www.ebi.ac.uk/pdbsum/4klz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klz ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ab E]]
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[[Category: Andrews M]]
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[[Category: Hoedemaeker FJ]]
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[[Category: Keizers PH]]
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[[Category: Kobayashi M]]
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[[Category: Manning L]]
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[[Category: Rzepiela AA]]
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[[Category: Shah DM]]
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[[Category: Siegal G]]
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[[Category: Tuin AW]]

Current revision

Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis

PDB ID 4klz

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