2h63

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[[Image:2h63.gif|left|200px]]<br /><applet load="2h63" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2h63, resolution 2.70&Aring;" />
 
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'''Crystal Structure of Human Biliverdin Reductase A (CASP Target)'''<br />
 
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==About this Structure==
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==Crystal Structure of Human Biliverdin Reductase A==
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2H63 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAP:'>NAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H63 OCA].
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<StructureSection load='2h63' size='340' side='right'caption='[[2h63]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Biliverdin reductase]]
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2h63]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H63 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h63 OCA], [https://pdbe.org/2h63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h63 RCSB], [https://www.ebi.ac.uk/pdbsum/2h63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h63 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BIEA_HUMAN BIEA_HUMAN] Defects in BLVRA are the cause of hyperbiliverdinemia (HBLVD) [MIM:[https://omim.org/entry/614156 614156]. HBLVD is a condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis.
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== Function ==
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[https://www.uniprot.org/uniprot/BIEA_HUMAN BIEA_HUMAN] Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/2h63_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h63 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Pilka E]]
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[[Category: Pilka, E.]]
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[[Category: Smee C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: NAP]]
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[[Category: biliverdin reductase]]
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[[Category: blvra]]
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[[Category: oxidoreductase]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:38:31 2008''
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Current revision

Crystal Structure of Human Biliverdin Reductase A

PDB ID 2h63

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