4fia
From Proteopedia
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| - | {{STRUCTURE_4fia| PDB=4fia | SCENE= }} | ||
| - | ===Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound=== | ||
| - | {{ABSTRACT_PUBMED_23288837}} | ||
| - | == | + | ==Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound== |
| - | [[ | + | <StructureSection load='4fia' size='340' side='right'caption='[[4fia]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FIA FirstGlance]. <br> |
| - | [[4fia]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0U9:S-BICALUTAMIDE'>0U9</scene>, <scene name='pdbligand=198:R-BICALUTAMIDE'>198</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fia OCA], [https://pdbe.org/4fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fia RCSB], [https://www.ebi.ac.uk/pdbsum/4fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fia ProSAT]</span></td></tr> |
| - | < | + | </table> |
| - | [[ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mast N]] |
| - | [[Category: | + | [[Category: Pikuleva IA]] |
| - | [[Category: | + | [[Category: Stout CD]] |
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Current revision
Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound
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