4bq6

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{{STRUCTURE_4bq6| PDB=4bq6 | SCENE= }}
 
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===Crystal structure of the RGMB-NEO1 complex form 1===
 
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{{ABSTRACT_PUBMED_23744777}}
 
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==Function==
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==Crystal structure of the RGMB-NEO1 complex form 1==
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[[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
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<StructureSection load='4bq6' size='340' side='right'caption='[[4bq6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bq6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQ6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq6 OCA], [https://pdbe.org/4bq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bq6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes including motility and adhesion, immune cell regulation and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called Dragon). The RGMB structure reveals a novel protein fold, a functionally important autocatalytic cleavage mechanism and provides a framework to explain numerous disease-linked mutations in RGMs. In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors, in a pH-dependent manner. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways.
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==About this Structure==
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Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub.,Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJ, Aricescu AR, Pasterkamp RJ, Siebold C Science. 2013 Jun 6. PMID:23744777<ref>PMID:23744777</ref>
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[[4bq6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ6 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023744777</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4bq6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Aricescu, A R.]]
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[[Category: Aricescu AR]]
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[[Category: Bell, C H.]]
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[[Category: Bell CH]]
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[[Category: Bishop, B.]]
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[[Category: Bishop B]]
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[[Category: Erp, S van.]]
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[[Category: Gilbert RJC]]
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[[Category: Gilbert, R J.C.]]
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[[Category: Healey E]]
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[[Category: Healey, E.]]
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[[Category: Pasterkamp RJ]]
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[[Category: Pasterkamp, R J.]]
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[[Category: Siebold C]]
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[[Category: Siebold, C.]]
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[[Category: Tang C]]
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[[Category: Tang, C.]]
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[[Category: Van Erp S]]
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[[Category: Cell adhesion]]
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Current revision

Crystal structure of the RGMB-NEO1 complex form 1

PDB ID 4bq6

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