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4fx8

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{{STRUCTURE_4fx8| PDB=4fx8 | SCENE= }}
 
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===Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
 
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{{ABSTRACT_PUBMED_23030629}}
 
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==Function==
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==Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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<StructureSection load='4fx8' size='340' side='right'caption='[[4fx8]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FX8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9411&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fx8 OCA], [https://pdbe.org/4fx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4fx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fx8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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==About this Structure==
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==See Also==
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[[4fx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX8 OCA].
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Methanothermobacter thermautotrophicus str. delta h]]
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Desai B]]
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[[Category: Desai, B.]]
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[[Category: Fedorov AA]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov EV]]
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[[Category: Fedorov, E V.]]
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[[Category: Gerlt JA]]
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[[Category: Gerlt, J A.]]
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[[Category: Inhibitor bmp]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Tim barrel]]
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Current revision

Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

PDB ID 4fx8

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