3vmj

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{{STRUCTURE_3vmj| PDB=3vmj | SCENE= }}
 
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===3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1===
 
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{{ABSTRACT_PUBMED_22442218}}
 
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==Function==
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==3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1==
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[[http://www.uniprot.org/uniprot/LEU3_SHEON LEU3_SHEON]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
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<StructureSection load='3vmj' size='340' side='right'caption='[[3vmj]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VMJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPM:3-ISOPROPYLMALIC+ACID'>IPM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vmj OCA], [https://pdbe.org/3vmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vmj RCSB], [https://www.ebi.ac.uk/pdbsum/3vmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vmj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEU3_SHEON LEU3_SHEON] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Organisms living in deep seas such as the Mariana Trench must be adapted to the extremely high pressure environment. For example, the 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 (SbIPMDH) remains active in extreme conditions under which that from the land bacterium S. oneidensis MR-1 (SoIPMDH) becomes inactivated. In order to unravel the differences between these two IPMDHs, their structures were determined at ~1.5 A resolution. Comparison of the structures of the two enzymes shows that SbIPMDH is in a more open form and has a larger internal cavity volume than SoIPMDH at atmospheric pressure. This loosely packed structure of SbIPMDH could help it to avoid pressure-induced distortion of the native structure and to remain active at higher pressures than SoIPMDH.
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==About this Structure==
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Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1.,Nagae T, Kato C, Watanabe N Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):265-8. Epub, 2012 Feb 15. PMID:22442218<ref>PMID:22442218</ref>
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[[3vmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Shewanella_oneidensis_mr-1 Shewanella oneidensis mr-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VMJ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:022442218</ref><references group="xtra"/><references/>
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</div>
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[[Category: 3-isopropylmalate dehydrogenase]]
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<div class="pdbe-citations 3vmj" style="background-color:#fffaf0;"></div>
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[[Category: Shewanella oneidensis mr-1]]
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[[Category: Nagae, T.]]
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==See Also==
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[[Category: Watanabe, N.]]
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*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
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[[Category: Decarboxylating dehydrogenase]]
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== References ==
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[[Category: Oxidoreductase]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Shewanella oneidensis MR-1]]
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[[Category: Nagae T]]
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[[Category: Watanabe N]]

Current revision

3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1

PDB ID 3vmj

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