4hl8

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{{STRUCTURE_4hl8| PDB=4hl8 | SCENE= }}
 
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===Re-refinement of the vault ribonucleoprotein particle===
 
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{{ABSTRACT_PUBMED_19150846}}
 
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==Function==
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==Re-refinement of the vault ribonucleoprotein particle==
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[[http://www.uniprot.org/uniprot/MVP_RAT MVP_RAT]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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<StructureSection load='4hl8' size='340' side='right'caption='[[4hl8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4hl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL8 FirstGlance]. <br>
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[[4hl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL8 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl8 OCA], [https://pdbe.org/4hl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl8 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl8 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:019150846</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/MVP_RAT MVP_RAT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Casanas, A.]]
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[[Category: Casanas A]]
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[[Category: Fita, I.]]
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[[Category: Fita I]]
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[[Category: Guerra, P.]]
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[[Category: Guerra P]]
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[[Category: Pous, J.]]
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[[Category: Pous J]]
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[[Category: Querol-Audi, J.]]
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[[Category: Querol-Audi J]]
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[[Category: Tanaka, H.]]
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[[Category: Tanaka H]]
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[[Category: Tsukihara, T.]]
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[[Category: Tsukihara T]]
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[[Category: Verdaguer, V.]]
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[[Category: Verdaguer V]]
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[[Category: 9 repeat domain]]
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[[Category: Cytoplasmic]]
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[[Category: Protein-protein complex]]
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[[Category: Ribonucleoprotein]]
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[[Category: Structural protein]]
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Current revision

Re-refinement of the vault ribonucleoprotein particle

PDB ID 4hl8

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