3w4k

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{{STRUCTURE_3w4k| PDB=3w4k | SCENE= }}
 
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===Crystal Structure of human DAAO in complex with coumpound 13===
 
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{{ABSTRACT_PUBMED_23566269}}
 
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==Function==
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==Crystal Structure of human DAAO in complex with coumpound 13==
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[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
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<StructureSection load='3w4k' size='340' side='right'caption='[[3w4k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w4k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W4K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LD:3-HYDROXY-6-(2-PHENYLETHYL)PYRIDAZIN-4(1H)-ONE'>3LD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w4k OCA], [https://pdbe.org/3w4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w4k RCSB], [https://www.ebi.ac.uk/pdbsum/3w4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w4k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
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==About this Structure==
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==See Also==
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[[3w4k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4K OCA].
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023566269</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: D-amino-acid oxidase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hamajima, T.]]
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[[Category: Large Structures]]
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[[Category: Harada, K.]]
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[[Category: Hamajima T]]
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[[Category: Hondo, T.]]
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[[Category: Harada K]]
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[[Category: Matsumoto, Y.]]
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[[Category: Hondo T]]
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[[Category: Nakanishi, K.]]
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[[Category: Matsumoto Y]]
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[[Category: Namatame, I.]]
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[[Category: Nakanishi K]]
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[[Category: Niimi, T.]]
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[[Category: Namatame I]]
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[[Category: Orita, M.]]
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[[Category: Niimi T]]
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[[Category: Sakashita, H.]]
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[[Category: Orita M]]
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[[Category: Takeuchi, M.]]
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[[Category: Sakashita H]]
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[[Category: Warizaya, M.]]
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[[Category: Takeuchi M]]
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[[Category: Watanabe, T.]]
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[[Category: Warizaya M]]
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[[Category: Yamaguchi, T.]]
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[[Category: Watanabe T]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Yamaguchi T]]

Current revision

Crystal Structure of human DAAO in complex with coumpound 13

PDB ID 3w4k

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