4e86

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{{STRUCTURE_4e86| PDB=4e86 | SCENE= }}
 
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===Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)===
 
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{{ABSTRACT_PUBMED_22573326}}
 
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==Function==
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==Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)==
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[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
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<StructureSection load='4e86' size='340' side='right'caption='[[4e86]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e86]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E86 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e86 OCA], [https://pdbe.org/4e86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e86 RCSB], [https://www.ebi.ac.uk/pdbsum/4e86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e86 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
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==About this Structure==
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==See Also==
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[[4e86]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA].
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*[[Defensin 3D structures|Defensin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022573326</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Pazgier, M.]]
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</StructureSection>
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[[Category: Wu, X.]]
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[[Category: Homo sapiens]]
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[[Category: Antimicrobial peptide]]
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[[Category: Large Structures]]
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[[Category: Antimicrobial protein]]
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[[Category: Pazgier M]]
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[[Category: Beta-sheet]]
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[[Category: Wu X]]
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[[Category: Mutant leu29aba]]
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[[Category: Paneth cell]]
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Current revision

Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)

PDB ID 4e86

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