2hc0
From Proteopedia
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| - | [[Image:2hc0.gif|left|200px]]<br /><applet load="2hc0" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2hc0, resolution 1.3Å" /> | ||
| - | '''Structure of HIV protease 6X mutant in complex with AB-2.'''<br /> | ||
| - | == | + | ==Structure of HIV protease 6X mutant in complex with AB-2.== |
| - | + | <StructureSection load='2hc0' size='340' side='right'caption='[[2hc0]], [[Resolution|resolution]] 1.30Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[2hc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HC0 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB2:[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL+(1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE'>AB2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc0 OCA], [https://pdbe.org/2hc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hc0 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/Q9E3M8_HV1 Q9E3M8_HV1] | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/2hc0_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hc0 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brik A]] | ||
| + | [[Category: Elder JH]] | ||
| + | [[Category: Heaslet H]] | ||
| + | [[Category: Lin Y-C]] | ||
| + | [[Category: Stout CD]] | ||
Current revision
Structure of HIV protease 6X mutant in complex with AB-2.
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