2m6n

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{{STRUCTURE_2m6n| PDB=2m6n | SCENE= }}
 
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===3D solution structure of EMI1 (Early Mitotic Inhibitor 1)===
 
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{{ABSTRACT_PUBMED_23708605}}
 
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==Function==
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==3D solution structure of EMI1 (Early Mitotic Inhibitor 1)==
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[[http://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN]] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref>
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<StructureSection load='2m6n' size='340' side='right'caption='[[2m6n]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2m6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M6N FirstGlance]. <br>
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[[2m6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6N OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6n OCA], [https://pdbe.org/2m6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m6n RCSB], [https://www.ebi.ac.uk/pdbsum/2m6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m6n ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023708605</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FBX5_HUMAN FBX5_HUMAN] Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.<ref>PMID:11988738</ref> <ref>PMID:16921029</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brown, N G.]]
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[[Category: Large Structures]]
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[[Category: Frye, J J.]]
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[[Category: Brown NG]]
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[[Category: Jarvis, M.]]
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[[Category: Frye JJ]]
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[[Category: Kriwacki, R W.]]
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[[Category: Jarvis M]]
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[[Category: Nourse, A.]]
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[[Category: Kriwacki RW]]
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[[Category: Peters, J.]]
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[[Category: Nourse A]]
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[[Category: Petzold, G.]]
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[[Category: Peters J]]
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[[Category: Royappa, G R.]]
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[[Category: Petzold G]]
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[[Category: Schulman, B A.]]
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[[Category: Royappa GR]]
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[[Category: Stark, H.]]
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[[Category: Schulman BA]]
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[[Category: Watson, E R.]]
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[[Category: Stark H]]
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[[Category: Apc]]
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[[Category: Watson ER]]
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[[Category: Cell cycle]]
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[[Category: E3 ligase]]
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[[Category: Emi1]]
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[[Category: Zbr]]
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Current revision

3D solution structure of EMI1 (Early Mitotic Inhibitor 1)

PDB ID 2m6n

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