4fzb
From Proteopedia
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- | {{STRUCTURE_4fzb| PDB=4fzb | SCENE= }} | ||
- | ===Structure of thymidylate synthase ThyX complexed to a new inhibitor=== | ||
- | {{ABSTRACT_PUBMED_23155486}} | ||
- | == | + | ==Structure of thymidylate synthase ThyX complexed to a new inhibitor== |
- | [[ | + | <StructureSection load='4fzb' size='340' side='right'caption='[[4fzb]], [[Resolution|resolution]] 2.59Å' scene=''> |
- | + | == Structural highlights == | |
- | == | + | <table><tr><td colspan='2'>[[4fzb]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZB FirstGlance]. <br> |
- | [[4fzb]] is a 16 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VJ:2-HYDROXY-3-(4-METHOXYBENZYL)NAPHTHALENE-1,4-DIONE'>0VJ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |
- | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzb OCA], [https://pdbe.org/4fzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzb RCSB], [https://www.ebi.ac.uk/pdbsum/4fzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzb ProSAT]</span></td></tr> |
- | < | + | </table> |
- | [[Category: Paramecium bursaria | + | == Function == |
- | [[Category: Basta | + | [https://www.uniprot.org/uniprot/THYX_PBCV1 THYX_PBCV1] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity). |
- | [[Category: Becker | + | __TOC__ |
- | [[Category: Boum | + | </StructureSection> |
- | [[Category: Briffotaux | + | [[Category: Large Structures]] |
- | [[Category: Graille | + | [[Category: Paramecium bursaria Chlorella virus 1]] |
- | [[Category: Lamarre-Jouenne | + | [[Category: Basta T]] |
- | [[Category: Lambry | + | [[Category: Becker HF]] |
- | [[Category: Liebl | + | [[Category: Boum Y]] |
- | [[Category: Myllylkallio | + | [[Category: Briffotaux J]] |
- | [[Category: Skouloubris | + | [[Category: Graille M]] |
- | [[Category: Tilbeurgh | + | [[Category: Lamarre-Jouenne I]] |
- | + | [[Category: Lambry JC]] | |
- | + | [[Category: Liebl U]] | |
- | + | [[Category: Myllylkallio H]] | |
+ | [[Category: Skouloubris S]] | ||
+ | [[Category: Van Tilbeurgh H]] |
Current revision
Structure of thymidylate synthase ThyX complexed to a new inhibitor
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