4gv2

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{{STRUCTURE_4gv2| PDB=4gv2 | SCENE= }}
 
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===Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354===
 
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{{ABSTRACT_PUBMED_23742272}}
 
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==Function==
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==Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354==
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[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
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<StructureSection load='4gv2' size='340' side='right'caption='[[4gv2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GV2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ME:3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[(1R)-1-(PYRIDIN-2-YL)ETHYL]PROPANAMIDE'>5ME</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv2 OCA], [https://pdbe.org/4gv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4gv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the cellular targets are poorly characterized. Here we describe an inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3), a regulator of DNA repair and mitotic progression. In vitro profiling against 12 members of the enzyme family suggests selectivity for ARTD3, and crystal structures illustrate the molecular basis for inhibitor selectivity. The compound is active in cells, where it elicits ARTD3-specific effects at sub-micromolar concentration. Our results show that by targeting the nicotinamide binding site, selective inhibition can be achieved among the closest relatives of the validated clinical target, ADP-ribosyltransferase-1/poly(ADP-ribose) polymerase-1.
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==About this Structure==
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A PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.,Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schuler H ACS Chem Biol. 2013 Jun 6. PMID:23742272<ref>PMID:23742272</ref>
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[[4gv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV2 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023742272</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4gv2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Andersson, C D.]]
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[[Category: Large Structures]]
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[[Category: Ekblad, T.]]
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[[Category: Andersson CD]]
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[[Category: Elofsson, M.]]
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[[Category: Ekblad T]]
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[[Category: Karlberg, T.]]
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[[Category: Elofsson M]]
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[[Category: Lindgren, A E.G.]]
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[[Category: Karlberg T]]
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[[Category: Linusson, A.]]
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[[Category: Lindgren AEG]]
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[[Category: Schuler, H.]]
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[[Category: Linusson A]]
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[[Category: Spjut, S.]]
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[[Category: Schuler H]]
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[[Category: Thorsell, A G.]]
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[[Category: Spjut S]]
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[[Category: Weigelt, J.]]
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[[Category: Thorsell AG]]
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[[Category: Adp- ribosylation]]
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[[Category: Weigelt J]]
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[[Category: Adp-ribose]]
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[[Category: Adp-ribosylation]]
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[[Category: Artd transferase domain]]
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[[Category: Artd3]]
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[[Category: Nad]]
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[[Category: Parp3]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354

PDB ID 4gv2

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