4b03

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{{STRUCTURE_4b03| PDB=4b03 | SCENE= }}
 
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===6A Electron cryomicroscopy structure of immature Dengue virus serotype 1===
 
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{{ABSTRACT_PUBMED_23637416}}
 
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==Function==
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==6A Electron cryomicroscopy structure of immature Dengue virus serotype 1==
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[[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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<SX load='4b03' size='340' side='right' viewer='molstar' caption='[[4b03]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4b03]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B03 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b03 OCA], [https://pdbe.org/4b03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b03 RCSB], [https://www.ebi.ac.uk/pdbsum/4b03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b03 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-A resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.
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==About this Structure==
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Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.,Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416<ref>PMID:23637416</ref>
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[[4b03]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023637416</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4b03" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</SX>
[[Category: Dengue virus 1]]
[[Category: Dengue virus 1]]
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[[Category: Kostyuchenko, V A.]]
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[[Category: Large Structures]]
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[[Category: Lok, S M.]]
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[[Category: Kostyuchenko VA]]
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[[Category: Ng, T S.]]
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[[Category: Lok SM]]
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[[Category: Tan, L C.]]
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[[Category: Ng TS]]
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[[Category: Zhang, Q.]]
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[[Category: Tan LC]]
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[[Category: Flavivirus]]
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[[Category: Zhang Q]]
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[[Category: Prm protein]]
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[[Category: Virus]]
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Current revision

6A Electron cryomicroscopy structure of immature Dengue virus serotype 1

4b03, resolution 6.00Å

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