4ec2

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{{STRUCTURE_4ec2| PDB=4ec2 | SCENE= }}
 
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===Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous===
 
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{{ABSTRACT_PUBMED_23344952}}
 
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==Function==
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==Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous==
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[[http://www.uniprot.org/uniprot/FRDA_YEAST FRDA_YEAST]] Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.<ref>PMID:9180083</ref> <ref>PMID:9988680</ref> <ref>PMID:15961414</ref> <ref>PMID:16371422</ref> <ref>PMID:19884169</ref> <ref>PMID:17027502</ref>
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<StructureSection load='4ec2' size='340' side='right'caption='[[4ec2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ec2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec2 OCA], [https://pdbe.org/4ec2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FRDA_YEAST FRDA_YEAST] Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.<ref>PMID:9180083</ref> <ref>PMID:9988680</ref> <ref>PMID:15961414</ref> <ref>PMID:16371422</ref> <ref>PMID:19884169</ref> <ref>PMID:17027502</ref>
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==About this Structure==
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==See Also==
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[[4ec2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC2 OCA].
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*[[Frataxin 3D Structures|Frataxin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023344952</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Ferroxidase]]
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</StructureSection>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Large Structures]]
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[[Category: Al-Karadaghi, S.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gakh, O.]]
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[[Category: Al-Karadaghi S]]
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[[Category: Isaya, G.]]
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[[Category: Gakh O]]
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[[Category: Rajan, S.]]
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[[Category: Isaya G]]
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[[Category: Soderberg, C A.G.]]
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[[Category: Rajan S]]
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[[Category: Alpha/beta sandwich]]
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[[Category: Soderberg CAG]]
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[[Category: Iron-storage]]
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[[Category: Metallochaperone]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous

PDB ID 4ec2

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