4e1k

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{{STRUCTURE_4e1k| PDB=4e1k | SCENE= }}
 
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===GlmU in complex with a Quinazoline Compound===
 
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{{ABSTRACT_PUBMED_22721802}}
 
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==Function==
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==GlmU in complex with a Quinazoline Compound==
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[[http://www.uniprot.org/uniprot/GLMU_HAEIN GLMU_HAEIN]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:18029420</ref>
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<StructureSection load='4e1k' size='340' side='right'caption='[[4e1k]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0N5:N-{4-[(7-HYDROXY-6-METHOXYQUINAZOLIN-4-YL)AMINO]PHENYL}BENZAMIDE'>0N5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1k OCA], [https://pdbe.org/4e1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1k RCSB], [https://www.ebi.ac.uk/pdbsum/4e1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLMU_HAEIN GLMU_HAEIN] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:18029420</ref>
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==About this Structure==
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==See Also==
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[[4e1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1K OCA].
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*[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022721802</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Haemophilus influenzae rd kw20]]
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</StructureSection>
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[[Category: Doig, P.]]
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[[Category: Haemophilus influenzae Rd KW20]]
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[[Category: Larsen, N A.]]
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[[Category: Large Structures]]
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[[Category: Acyltransferase]]
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[[Category: Doig P]]
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[[Category: Cell shape]]
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[[Category: Larsen NA]]
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[[Category: Cell wall biogenesis/degradation]]
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[[Category: Metal-binding]]
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[[Category: Multifunctional enzyme]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Uridyltransferase]]
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Current revision

GlmU in complex with a Quinazoline Compound

PDB ID 4e1k

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