4je0

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{{STRUCTURE_4je0| PDB=4je0 | SCENE= }}
 
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===Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands===
 
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{{ABSTRACT_PUBMED_23549613}}
 
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==About this Structure==
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==Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands==
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[[4je0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_tch60 Staphylococcus aureus subsp. aureus tch60]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE0 OCA].
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<StructureSection load='4je0' size='340' side='right'caption='[[4je0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4je0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_TCH60 Staphylococcus aureus subsp. aureus TCH60]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JE0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4je0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je0 OCA], [https://pdbe.org/4je0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4je0 RCSB], [https://www.ebi.ac.uk/pdbsum/4je0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4je0 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Staphylococcus aureus is the most important Gram-positive colonizer of human skin and nasal passage, causing high morbidity and mortality. SD-repeat containing protein D (SdrD), an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family surface protein, plays an important role in S. aureus adhesion and pathogenesis, while its binding target and molecular mechanism remain largely unknown. Here we solved the crystal structures of SdrD N2-N3 domain and N2-N3-B1 domain. Through structural analysis and comparisons, we characterized the ligand binding site of SdrD, and proposed a featured sequence motif of its potential ligands. In addition, the structures revealed for the first time the interactions between B1 domain and N2-N3 domain among B domain-containing MSCRAMMs. Our results may help in understanding the roles SdrD plays in S. aureus adhesion and shed light on the development of novel antibiotics.
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==Reference==
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Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands.,Wang X, Ge J, Liu B, Hu Y, Yang M Protein Cell. 2013 Apr;4(4):277-85. doi: 10.1007/s13238-013-3009-x. Epub 2013 Apr, 3. PMID:23549613<ref>PMID:23549613</ref>
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<ref group="xtra">PMID:023549613</ref><references group="xtra"/><references/>
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[[Category: Staphylococcus aureus subsp. aureus tch60]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Ge, J.]]
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</div>
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[[Category: Wang, X.]]
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<div class="pdbe-citations 4je0" style="background-color:#fffaf0;"></div>
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[[Category: Yang, M.]]
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== References ==
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[[Category: Cell adhesion]]
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<references/>
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[[Category: Mscramm]]
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__TOC__
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[[Category: Receptor]]
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</StructureSection>
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[[Category: Staphylococcus aureus]]
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[[Category: Large Structures]]
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[[Category: Surface]]
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[[Category: Staphylococcus aureus subsp. aureus TCH60]]
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[[Category: Ge J]]
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[[Category: Wang X]]
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[[Category: Yang M]]

Current revision

Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands

PDB ID 4je0

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