4fz5

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{{STRUCTURE_4fz5| PDB=4fz5 | SCENE= }}
 
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===Crystal Structure of Human TIRAP TIR-domain===
 
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==Function==
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==Crystal Structure of Human TIRAP TIR-domain==
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[[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
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<StructureSection load='4fz5' size='340' side='right'caption='[[4fz5]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fz5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [https://pdbe.org/4fz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4fz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fz5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
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==About this Structure==
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==See Also==
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[[4fz5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA].
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*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kim, S.]]
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[[Category: Large Structures]]
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[[Category: Park, S.]]
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[[Category: Kim S]]
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[[Category: Shoelson, S E.]]
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[[Category: Park S]]
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[[Category: Woo, J R.]]
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[[Category: Shoelson SE]]
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[[Category: Immune system]]
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[[Category: Woo JR]]
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[[Category: Myd88]]
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[[Category: Scaffold]]
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[[Category: Tirap]]
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Current revision

Crystal Structure of Human TIRAP TIR-domain

PDB ID 4fz5

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