3tz2

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{{STRUCTURE_3tz2| PDB=3tz2 | SCENE= }}
 
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===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex===
 
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==Function==
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==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex==
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[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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<StructureSection load='3tz2' size='340' side='right'caption='[[3tz2]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3tz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZ2 FirstGlance]. <br>
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[[3tz2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLT:4-PHENYL-BUTANOIC+ACID'>CLT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz2 OCA], [https://pdbe.org/3tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tz2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chuang, D T.]]
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[[Category: Chuang DT]]
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[[Category: Chuang, J L.]]
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[[Category: Chuang JL]]
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[[Category: Gui, W J.]]
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[[Category: Gui WJ]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Tso, S C.]]
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[[Category: Tso SC]]
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[[Category: Wynn, R M.]]
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[[Category: Wynn RM]]
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[[Category: Allosteric kinase inhibitor]]
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[[Category: Bergerat nucleotide-binding fold]]
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[[Category: Branched-chain alpha-ketoacid]]
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[[Category: Branched-chain amino acid]]
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[[Category: Diabetes and obesity]]
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[[Category: Ghkl protein kinase]]
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[[Category: Maple syrup urine disease]]
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[[Category: Protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex

PDB ID 3tz2

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