4ivk

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{{STRUCTURE_4ivk| PDB=4ivk | SCENE= }}
 
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===Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin.===
 
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{{ABSTRACT_PUBMED_23737193}}
 
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==About this Structure==
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==Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin.==
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[[4ivk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_bacterium Uncultured bacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IVK OCA].
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<StructureSection load='4ivk' size='340' side='right'caption='[[4ivk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ivk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_bacterium Uncultured bacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IVK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEP:CEPHALOTHIN+GROUP'>CEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ivk OCA], [https://pdbe.org/4ivk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ivk RCSB], [https://www.ebi.ac.uk/pdbsum/4ivk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ivk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/K4HQE7_9BACT K4HQE7_9BACT]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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EstU1 is a unique family VIII carboxylesterase that displays hydrolytic activity towards the amide bond of clinically used beta-lactam antibiotics as well as the ester bond of p-nitrophenyl esters. EstU1 assumes a beta-lactamase-like modular architecture and contains the residues Ser100, Lys103, and Tyr218, which correspond to the three catalytic residues (Ser64, Lys67, and Tyr150, respectively) of class C beta-lactamases. The structure of the EstU1/cephalothin complex demonstrates that the active site of EstU1 is not ideally tailored to perform an efficient deacylation reaction during the hydrolysis of beta-lactam antibiotics. This result explains the weak beta-lactamase activity of EstU1 compared with class C beta-lactamases. Finally, structural and sequential comparison of EstU1 with other family VIII carboxylesterases elucidates an operative molecular strategy used by family VIII carboxylesterases to extend their substrate spectrum. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.
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==Reference==
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Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase.,Cha SS, Jun An Y, Jeong CS, Kim MK, Jeon JH, Lee CM, Lee HS, Gyun Kang S, Lee JH Proteins. 2013 Jun 5. doi: 10.1002/prot.24334. PMID:23737193<ref>PMID:23737193</ref>
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<ref group="xtra">PMID:023737193</ref><references group="xtra"/><references/>
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[[Category: Carboxylesterase]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ivk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Uncultured bacterium]]
[[Category: Uncultured bacterium]]
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[[Category: An, Y J.]]
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[[Category: An YJ]]
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[[Category: Cha, S S.]]
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[[Category: Cha S-S]]
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[[Category: Jeong, C S.]]
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[[Category: Jeong C-S]]
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[[Category: Kim, M K.]]
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[[Category: Kim M-K]]
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[[Category: Deep sea sediment]]
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[[Category: Helical domain and a alpha/beta domain]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin.

PDB ID 4ivk

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