4ksl

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(New page: {{Large structure}} {{STRUCTURE_4ksl| PDB=4ksl | SCENE= }} ===Gumby/Fam105B in complex with linear di-ubiquitin=== ==Function== http://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN...)
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{{Large structure}}
 
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{{STRUCTURE_4ksl| PDB=4ksl | SCENE= }}
 
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===Gumby/Fam105B in complex with linear di-ubiquitin===
 
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==Function==
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==Gumby/Fam105B in complex with linear di-ubiquitin==
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[[http://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN]] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
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<StructureSection load='4ksl' size='340' side='right'caption='[[4ksl]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ksl]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksl OCA], [https://pdbe.org/4ksl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksl RCSB], [https://www.ebi.ac.uk/pdbsum/4ksl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OTUL_HUMAN OTUL_HUMAN] Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.<ref>PMID:23827681</ref> <ref>PMID:23806334</ref> <ref>PMID:23746843</ref> <ref>PMID:23708998</ref>
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==About this Structure==
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==See Also==
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[[4ksl]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSL OCA].
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ceccarelli, D F.]]
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[[Category: Large Structures]]
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[[Category: Juang, Y-C.]]
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[[Category: Ceccarelli DF]]
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[[Category: Sicheri, F.]]
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[[Category: Juang Y-C]]
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[[Category: Deubiquitinase]]
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[[Category: Sicheri F]]
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[[Category: Hydrolase]]
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[[Category: Linear diubiquitin]]
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[[Category: Otu domain]]
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Current revision

Gumby/Fam105B in complex with linear di-ubiquitin

PDB ID 4ksl

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