4ap8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:32, 20 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4ap8| PDB=4ap8 | SCENE= }}
 
-
===Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)===
 
-
==Disease==
+
==Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)==
-
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:[http://omim.org/entry/252150 252150]]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry.
+
<StructureSection load='4ap8' size='340' side='right'caption='[[4ap8]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[4ap8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AP8 FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<ref>PMID:12732628</ref> <ref>PMID:15073332</ref>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ap8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap8 OCA], [https://pdbe.org/4ap8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ap8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ap8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap8 ProSAT]</span></td></tr>
-
[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA].
+
</table>
-
 
+
== Disease ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:[https://omim.org/entry/252150 252150]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry.
-
<references group="xtra"/><references/>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<ref>PMID:12732628</ref> <ref>PMID:15073332</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Molybdopterin synthase]]
+
[[Category: Large Structures]]
-
[[Category: Allerston, C.]]
+
[[Category: Allerston C]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Froese DS]]
-
[[Category: Froese, D S.]]
+
[[Category: Goubin S]]
-
[[Category: Goubin, S.]]
+
[[Category: Kiyani W]]
-
[[Category: Kiyani, W.]]
+
[[Category: Krojer T]]
-
[[Category: Krojer, T.]]
+
[[Category: Vollmar M]]
-
[[Category: Vollmar, M.]]
+
[[Category: Yue WW]]
-
[[Category: Yue, W W.]]
+
[[Category: Von Delft F]]
-
[[Category: Transferase]]
+

Current revision

Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)

PDB ID 4ap8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ap8"
Personal tools