4br1

{{STRUCTURE_4br1| PDB=4br1 | SCENE= }}

===Protease-induced heterodimer of human triosephosphate isomerase.===

==Disease==

[[http://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[http://omim.org/entry/190450 190450]]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

==About this Structure==

[[4br1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BR1 OCA].

[[Category: Triose-phosphate isomerase]]

[[Category: Castillo-Villanueva, A.]]

[[Category: DeLaMora-DeLaMora, I.]]

[[Category: Enriquez-Flores, S.]]

[[Category: Garcia-Torres, I.]]

[[Category: Gomez-Manzo, S.]]

[[Category: Hernandez-Alcantara, G.]]

[[Category: Lopez-Velazquez, G.]]

[[Category: Marcial-Quino, J.]]

[[Category: Mendez, S T.]]

[[Category: Mendoza-Hernandez, G.]]

[[Category: Oria-Hernandez, J.]]

[[Category: Reyes-Vivas, H.]]

[[Category: Torres-Arroyo, A.]]

[[Category: Torres-Larios, A.]]

[[Category: Protease degradation]]