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4ii6

From Proteopedia

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{{STRUCTURE_4ii6| PDB=4ii6 | SCENE= }}
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#REDIRECT [[4wvd]] This PDB entry is obsolete and replaced by 4wvd
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===Identification of a novel FXR ligand that regulates metabolism===
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==Function==
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[[http://www.uniprot.org/uniprot/NCOR1_HUMAN NCOR1_HUMAN]] Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.<ref>PMID:14527417</ref> [[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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==About this Structure==
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[[4ii6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II6 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Li, Y.]]
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[[Category: Wang, R.]]
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[[Category: Af-2 helix]]
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[[Category: Bar]]
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[[Category: Bile acid receptor]]
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[[Category: Corepressor]]
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[[Category: Ligand binding pocket]]
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[[Category: Nhr]]
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[[Category: Nr1h4]]
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[[Category: Nuclear receptor]]
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[[Category: Three-layer helical sandwich]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator fxr]]
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Current revision

  1. REDIRECT 4wvd This PDB entry is obsolete and replaced by 4wvd

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