2yn2

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{{STRUCTURE_2yn2| PDB=2yn2 | SCENE= }}
 
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===Huf protein - paralogue of the tau55 histidine phosphatase domain===
 
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{{ABSTRACT_PUBMED_23569204}}
 
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==About this Structure==
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==Huf protein - paralogue of the tau55 histidine phosphatase domain==
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[[2yn2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN2 OCA].
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<StructureSection load='2yn2' size='340' side='right'caption='[[2yn2]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2yn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YN2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn2 OCA], [https://pdbe.org/2yn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yn2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YNK8_YEAST YNK8_YEAST]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Saccharomyces cerevisiae tau55, a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an N-terminal histidine phosphatase domain (tau55-HPD) whose catalytic activity and cellular function is poorly understood. We solved the crystal structures of tau55-HPD and its closely related paralogue Huf and used in silico docking methods to identify phospho-serine and phospho-tyrosine containing peptides as possible substrates that were subsequently validated using in vitro phosphatase assays. A comparative phospho-proteomic study identified additional phosphopeptides as possible targets, which show the involvement of these two phosphatases in the regulation of a variety of cellular functions. Our results identify tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities and provide a small set of regulated phosphosite targets in vivo.
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==Reference==
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Structural and functional characterization of a phosphatase domain within yeast general transcription factor TFIIIC.,Taylor NM, Glatt S, Hennrich ML, von Scheven G, Grotsch H, Fernandez-Tornero C, Rybin V, Gavin AC, Kolb P, Muller CW J Biol Chem. 2013 Apr 8. PMID:23569204<ref>PMID:23569204</ref>
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<ref group="xtra">PMID:023569204</ref><references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Fernandez-Tornero, C.]]
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</div>
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[[Category: Gavin, A C.]]
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<div class="pdbe-citations 2yn2" style="background-color:#fffaf0;"></div>
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[[Category: Glatt, S.]]
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== References ==
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[[Category: Grotsch, H.]]
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<references/>
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[[Category: Hennrich, M.]]
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__TOC__
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[[Category: Kolb, P.]]
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</StructureSection>
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[[Category: Muller, C W.]]
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[[Category: Large Structures]]
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[[Category: Rybin, V.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Scheven, G von.]]
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[[Category: Fernandez-Tornero C]]
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[[Category: Taylor, N M.I.]]
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[[Category: Gavin AC]]
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[[Category: Histidine phosphatase domain]]
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[[Category: Glatt S]]
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[[Category: Hydrolase]]
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[[Category: Grotsch H]]
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[[Category: Phosphoglycerate mutase domain]]
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[[Category: Hennrich M]]
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[[Category: Kolb P]]
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[[Category: Muller CW]]
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[[Category: Rybin V]]
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[[Category: Taylor NMI]]
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[[Category: Von Scheven G]]

Current revision

Huf protein - paralogue of the tau55 histidine phosphatase domain

PDB ID 2yn2

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