2m7f
From Proteopedia
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| - | {{STRUCTURE_2m7f| PDB=2m7f | SCENE= }} | ||
| - | ===The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions=== | ||
| - | == | + | ==The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions== |
| - | [[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH | + | <StructureSection load='2m7f' size='340' side='right'caption='[[2m7f]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7f OCA], [https://pdbe.org/2m7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7f RCSB], [https://www.ebi.ac.uk/pdbsum/2m7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Disintegrin|Disintegrin]] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Calloselasma rhodostoma]] | [[Category: Calloselasma rhodostoma]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chang Y]] |
| - | [[Category: | + | [[Category: Chuang W]] |
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Current revision
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions
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