4gr0

{{STRUCTURE_4gr0| PDB=4gr0 | SCENE= }}

===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B===

{{ABSTRACT_PUBMED_23343195}}

==Function==

[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

==About this Structure==

[[4gr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR0 OCA].

 

<ref group="xtra">PMID:023343195</ref><references group="xtra"/><references/>

[[Category: Macrophage elastase]]

[[Category: Beau, F.]]

[[Category: Cassar-Lajeunesse, E.]]

[[Category: Devel, L.]]

[[Category: Dive, V.]]

[[Category: Stura, E A.]]

[[Category: Vera, L.]]

[[Category: Zinc protease]]