This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4bsr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{STRUCTURE_4bsr| PDB=4bsr | SCENE= }} ===Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form=== ==Disease== [[http://www.uniprot.org/unip...)
Current revision (17:05, 7 September 2022) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4bsr| PDB=4bsr | SCENE= }}
 
-
===Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form===
 
-
==Disease==
+
==Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form==
-
[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
+
<StructureSection load='4bsr' size='340' side='right'caption='[[4bsr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[4bsr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BSR FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/LGR5_HUMAN LGR5_HUMAN]] Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling. [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsr OCA], [https://pdbe.org/4bsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bsr RCSB], [https://www.ebi.ac.uk/pdbsum/4bsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsr ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[4bsr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSR OCA].
+
== Function ==
-
 
+
[[https://www.uniprot.org/uniprot/LGR5_HUMAN LGR5_HUMAN]] Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling.
-
==Reference==
+
__TOC__
-
<references group="xtra"/><references/>
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Clevers, H.]]
+
[[Category: Large Structures]]
-
[[Category: Forneris, F.]]
+
[[Category: Clevers H]]
-
[[Category: Granneman, J C.M.]]
+
[[Category: Forneris F]]
-
[[Category: Gros, P.]]
+
[[Category: Granneman JCM]]
-
[[Category: Huch, M.]]
+
[[Category: Gros P]]
-
[[Category: Lau, W de.]]
+
[[Category: Huch M]]
-
[[Category: Peng, W C.]]
+
[[Category: Peng WC]]
-
[[Category: Adult stem cell]]
+
[[Category: De Lau W]]
-
[[Category: Congenital anonychia]]
+
-
[[Category: Furin domain]]
+
-
[[Category: Leucine-rich repeat]]
+
-
[[Category: Leucine-rich repeat g-protein coupled receptor]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Wnt signaling]]
+

Current revision

Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in P22121 crystal form

PDB ID 4bsr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bsr"
Personal tools