4kre
From Proteopedia
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| - | {{STRUCTURE_4kre| PDB=4kre | SCENE= }} | ||
| - | ===Structure of Human Argonaute-1 bound to endogenous Sf9 RNA=== | ||
| - | == | + | ==Structure of Human Argonaute-1 bound to endogenous Sf9 RNA== |
| - | [[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN | + | <StructureSection load='4kre' size='340' side='right'caption='[[4kre]], [[Resolution|resolution]] 1.75Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KRE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.754Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kre OCA], [https://pdbe.org/4kre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kre RCSB], [https://www.ebi.ac.uk/pdbsum/4kre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kre ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Argonaute 3D structures|Argonaute 3D structures]] |
| - | + | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |
| - | == | + | == References == |
| - | <references | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Spodoptera frugiperda]] | [[Category: Spodoptera frugiperda]] | ||
| - | [[Category: Elkayam | + | [[Category: Elkayam E]] |
| - | [[Category: Faehnle | + | [[Category: Faehnle CR]] |
| - | [[Category: Joshua-Tor | + | [[Category: Joshua-Tor L]] |
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Current revision
Structure of Human Argonaute-1 bound to endogenous Sf9 RNA
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