4ky3

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{{STRUCTURE_4ky3| PDB=4ky3 | SCENE= }}
 
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===Three-dimensional Structure of the orthorhombic crystal of computationally designed insertion domain , Northeast Structural Genomics Consortium (NESG) Target OR327===
 
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==About this Structure==
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==Three-dimensional Structure of the orthorhombic crystal of computationally designed insertion domain , Northeast Structural Genomics Consortium (NESG) Target OR327==
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[[4ky3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY3 OCA].
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<StructureSection load='4ky3' size='340' side='right'caption='[[4ky3]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ky3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KY3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.964&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ky3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky3 OCA], [https://pdbe.org/4ky3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ky3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ky3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ky3 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Design of complex alpha-beta protein topologies poses a challenge because of the large number of alternative packing arrangements. A similar challenge presumably limited the emergence of large and complex protein topologies in evolution. Here we demonstrate that protein topologies with six and seven-stranded beta sheets can be designed by insertion of one de novo designed beta sheet containing protein into another such that the two beta sheets are merged to form a single extended sheet, followed by amino acid sequence optimization at the newly formed strand-strand, strand-helix, and helix-helix interfaces. Crystal structures of two such designs closely match the computational design models. Searches for similar structures in the SCOP protein domain database yield only weak matches with different beta sheet connectivities. A similar beta sheet fusion mechanism may have contributed to the emergence of complex beta sheets during natural protein evolution.
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Precise assembly of complex beta sheet topologies from de novo designed building blocks.,King IC, Gleixner J, Doyle L, Kuzin A, Hunt JF, Xiao R, Montelione GT, Stoddard BL, DiMaio F, Baker D Elife. 2015 Dec 9;4. pii: e11012. doi: 10.7554/eLife.11012. PMID:26650357<ref>PMID:26650357</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ky3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
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[[Category: Acton, T B.]]
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[[Category: Acton TB]]
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[[Category: Baker, D.]]
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[[Category: Baker D]]
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[[Category: Everett, J K.]]
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[[Category: Everett JK]]
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[[Category: Gleixner, J.]]
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[[Category: Gleixner J]]
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[[Category: Hunt, J F.]]
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[[Category: Hunt JF]]
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[[Category: Kuzin, A.]]
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[[Category: Kuzin A]]
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[[Category: Lee, D.]]
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[[Category: Lee D]]
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[[Category: Maglaqui, M.]]
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[[Category: Maglaqui M]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Seetharaman J]]
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[[Category: Seetharaman, J.]]
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[[Category: Su M]]
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[[Category: Su, M.]]
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[[Category: Tong L]]
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[[Category: Tong, L.]]
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[[Category: Xiao R]]
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[[Category: Xiao, R.]]
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[[Category: De novo protein]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Three-dimensional Structure of the orthorhombic crystal of computationally designed insertion domain , Northeast Structural Genomics Consortium (NESG) Target OR327

PDB ID 4ky3

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