4edm

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{{STRUCTURE_4edm| PDB=4edm | SCENE= }}
 
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===Crystal structure of beta-parvin CH2 domain===
 
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{{ABSTRACT_PUBMED_22869380}}
 
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==Function==
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==Crystal structure of beta-parvin CH2 domain==
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[[http://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN]] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref>
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<StructureSection load='4edm' size='340' side='right'caption='[[4edm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4edm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edm OCA], [https://pdbe.org/4edm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edm RCSB], [https://www.ebi.ac.uk/pdbsum/4edm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref>
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==About this Structure==
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==See Also==
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[[4edm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDM OCA].
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*[[Parvin 3D structures|Parvin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022869380</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boggon, T J.]]
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[[Category: Large Structures]]
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[[Category: Calderwood, D A.]]
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[[Category: Boggon TJ]]
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[[Category: Chayen, N E.]]
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[[Category: Calderwood DA]]
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[[Category: Draheim, K M.]]
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[[Category: Chayen NE]]
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[[Category: Li, X.]]
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[[Category: Draheim KM]]
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[[Category: Stiegler, A L.]]
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[[Category: Li X]]
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[[Category: Adaptor protein]]
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[[Category: Stiegler AL]]
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[[Category: Calponin homology domain]]
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[[Category: Focal adhesion]]
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[[Category: Integrin linked kinase]]
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[[Category: Integrin signaling]]
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[[Category: Ld motif]]
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[[Category: Paxillin]]
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[[Category: Protein-protein interaction]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of beta-parvin CH2 domain

PDB ID 4edm

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