Tumor necrosis factor

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(New page: <StructureSection load='3alq' size='350' side='right' caption='Structure of human tumor necrosis factor complex with TNF receptor (PDB entry 3alq)' scene=''> '''Tumor necrosis factor...)
Current revision (11:08, 5 February 2024) (edit) (undo)
 
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<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
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== Function ==
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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]].
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<StructureSection load='3alq' size='350' side='right' caption='Structure of human tumor necrosis factor complex with TNF receptor (PDB entry [[3alq]])' scene=''>
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== Relevance ==
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TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>.
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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
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== Structural highlights ==
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The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
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== 3D Structures of tumor necrosis factor ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== 3D Structures of tumor necrosis factor ==
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===TNF alpha===
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[[Tumor necrosis factor 3D structures]]
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[[1tnf]] – hTNF – human <BR />
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== References ==
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[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant) <BR />
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<references/>
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[[2tnf]] – TNF – mouse <BR />
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</StructureSection>
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[[2az5]] – hTNF + inhibitor <BR />
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[[Category:Topic Page]]
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[[3it8]] – hTNF + poxvirus 2L protein <BR />
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[[3l9j]] – hTNF + antagonist <BR />
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[[3alq]] – hTNF (mutant) + TNF receptor <BR />
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[[4g3y]] – hTNF + antibody <BR />
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Current revision

Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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